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APC Proteins

The initial identification of the Adenomatous polyposis eoli (Ape) gene as the site of mutations in familial adenomatous polyposis (FAP) was described in 1 1992. ,2 A causal relationship between Ape mutations and intestinal tract tumours was confirmed three years later with the establishment ofthe Min mouse model) These mice are heterozygous forApe and develop numerous intestinal tumo...

10397812 {"price-changing":0,"image":"https:\/\/image.vergleiche.ch\/small\/aHR0cHM6Ly9hc3NldHMudGhhbGlhLm1lZGlhL2ltZy9hcnRpa2VsLzNjNmExNzYyOTZmZDc1NTUzYjZiNmU0MWZjMjNmMjQ4MDhmYjA4ZWUtMDAtMDAuanBlZw==!aHR0cHM6Ly9hc3NldHMudGhhbGlhLm1lZGlhL2ltZy9hcnRpa2VsLzNjNmExNzYyOTZmZDc1NTUzYjZiNmU0MWZjMjNmMjQ4MDhmYjA4ZWUtMDAtMDAuanBlZw==","post_title":"APC Proteins","deeplink":"https:\/\/www.awin1.com\/pclick.php?p=25181052349&a=401125&m=13971&pref1=9781441911452","labels":[],"brand_id":15195,"post_content":"The initial identification of the Adenomatous polyposis eoli (Ape) gene as the site of mutations in familial adenomatous polyposis (FAP) was described in 1 1992. ,2 A causal relationship between Ape mutations and intestinal tract tumours was confirmed three years later with the establishment ofthe Min mouse model) These mice are heterozygous forApe and develop numerous intestinal tumours that mimic FAP. Subsequently, Ape has emerged as the most commonly mutated gene in colorectal cancerwith reports varying between 50-80% ofsporadic tumours car rying such mutations. The search for how mutations in Ape initiate and\/or support progression oftumours in the intestinal tract has revealed that the Ape protein is a multifunctionalparticipant in a diverse array ofcellular functions. By collecting and assembling the chapters inthisbook, we aimed toprovide an overview of the diverse functions performed by the Ape protein. As summarised in a short final chapter by Trainer,heterozygosityofApe leads to a number ofextracolonic manifestations that further support this emerging picture ofthe Ape protein as an active contributor to many different cellular functions. The first recognised function of Ape was its role in Wnt signalling. o This function is one of the driving forces for how mutations in Ape ensure that cells remain proliferative. Many of the molecular details of this pathway have been discovered and are described in the first chapter by Kennell and Cadigan.","merchants_number":1,"ean":9781441911452,"category_id":1,"size":null,"min_price":175.900000000000005684341886080801486968994140625,"low_price_merchant_id":70254503,"ID":10397812,"merchants":["orell-fuessli"],"brand":"SPRINGER","slug":"apc-proteins-1","url":"\/produkt\/apc-proteins-1\/","low_price_merchant_name":"Orell F\u00fcssli"}

CHF 120.00

Protein Families

New insights into the evolution and nature of proteins Exploring several distinct approaches, this book describes themethods for comparing protein sequences and protein structures inorder to identify homologous relationships and classify proteinsand protein domains into evolutionary families. Readers willdiscover the common features as well as the key philosophicaldifferences under...

10185082 {"price-changing":0,"image":"https:\/\/image.vergleiche.ch\/small\/aHR0cHM6Ly9hc3NldHMudGhhbGlhLm1lZGlhL2ltZy9hcnRpa2VsLzkxZDNjMTEyMGJlZTIxZDVkMjhkNTYyZjI5MDY5MGUxN2RhM2I3MjQtMDAtMDAuanBlZw==!aHR0cHM6Ly9hc3NldHMudGhhbGlhLm1lZGlhL2ltZy9hcnRpa2VsLzkxZDNjMTEyMGJlZTIxZDVkMjhkNTYyZjI5MDY5MGUxN2RhM2I3MjQtMDAtMDAuanBlZw==","post_title":"Protein Families","deeplink":"https:\/\/www.awin1.com\/pclick.php?p=25178859449&a=401125&m=13971&pref1=9781118742853","labels":[],"brand_id":327728,"post_content":"New insights into the evolution and nature of proteins Exploring several distinct approaches, this book describes themethods for comparing protein sequences and protein structures inorder to identify homologous relationships and classify proteinsand protein domains into evolutionary families. Readers willdiscover the common features as well as the key philosophicaldifferences underlying the major protein classification systems,including Pfam, Panther, SCOP, and CATH. Moreover, they'll discoverhow these systems can be used to understand the evolution ofprotein families as well as understand and predict the degree towhich structural and functional information are shared betweenrelatives in a protein family. Edited and authored by leading international experts, ProteinFamilies offers new insights into protein families that areimportant to medical research as well as protein families that helpus understand biological systems and key biological processes suchas cell signaling and the immune response. The book is divided intothree sections: * Section I: Concepts Underlying Protein FamilyClassification reviews the major strategies for identifyinghomologous proteins and classifying them into families. * Section II: In-Depth Reviews of Protein Families focuseson some fascinating super protein families for which we havesubstantial amounts of sequence, structural and functional data,making it possible to trace the emergence of functionally diverserelatives. * Section III: Review of Protein Families in ImportantBiological Systems examines protein families associated with aparticular biological theme, such as the cytoskeleton. All chapters are extensively illustrated, including depictionsof evolutionary relationships. References at the end of eachchapter guide readers to original research papers and reviews inthe field. Covering protein family classification systems alongsidedetailed descriptions of select protein families, this book offersbiochemists, molecular biologists, protein scientists, structuralbiologists, and bioinformaticians new insight into the evolutionand nature of proteins.","merchants_number":1,"ean":9781118742853,"category_id":1,"size":null,"min_price":120,"low_price_merchant_id":70254503,"ID":10185082,"merchants":["orell-fuessli"],"brand":"John Wiley & Sons Inc","slug":"protein-families","url":"\/produkt\/protein-families\/","low_price_merchant_name":"Orell F\u00fcssli"}

CHF 140.00

Moonlighting Proteins

Moonlighting Proteins: Novel Virulence Factors in Bacterial Infections is a complete examination of the ways in which proteins with more than one unique biological action are able to serve as virulence factors in different bacteria. The book explores the pathogenicity of bacterial moonlighting proteins, demonstrating the plasticity of protein evolution as it relates to protein functio...

10463398 {"price-changing":0,"image":"https:\/\/image.vergleiche.ch\/small\/aHR0cHM6Ly9hc3NldHMudGhhbGlhLm1lZGlhL2ltZy9hcnRpa2VsL2E1YWRkZmVkZDE0MGZiMWIxOTRlODYzZThhYTY3NzIxNzQ4NGE5NjAtMDAtMDAuanBlZw==!aHR0cHM6Ly9hc3NldHMudGhhbGlhLm1lZGlhL2ltZy9hcnRpa2VsL2E1YWRkZmVkZDE0MGZiMWIxOTRlODYzZThhYTY3NzIxNzQ4NGE5NjAtMDAtMDAuanBlZw==","post_title":"Moonlighting Proteins","deeplink":"https:\/\/www.awin1.com\/pclick.php?p=25181731261&a=401125&m=13971&pref1=9781118951132","labels":[],"brand_id":327728,"post_content":"Moonlighting Proteins: Novel Virulence Factors in Bacterial Infections is a complete examination of the ways in which proteins with more than one unique biological action are able to serve as virulence factors in different bacteria. The book explores the pathogenicity of bacterial moonlighting proteins, demonstrating the plasticity of protein evolution as it relates to protein function and to bacterial communication. Highlighting the latest discoveries in the field, it details the approximately 70 known bacterial proteins with a moonlighting function related to a virulence phenomenon. Chapters describe the ways in which each moonlighting protein can function as such for a variety of bacterial pathogens and how individual bacteria can use more than one moonlighting protein as a virulence factor. The cutting-edge research contained here offers important insights into many topics, from bacterial colonization, virulence, and antibiotic resistance, to protein structure and the therapeutic potential of moonlighting proteins. Moonlighting Proteins: Novel Virulence Factors in Bacterial Infections will be of interest to researchers and graduate students in microbiology (specifically bacteriology), immunology, cell and molecular biology, biochemistry, pathology, and protein science.","merchants_number":1,"ean":9781118951132,"category_id":1,"size":null,"min_price":140,"low_price_merchant_id":70254503,"ID":10463398,"merchants":["orell-fuessli"],"brand":"John Wiley & Sons Inc","slug":"moonlighting-proteins-1","url":"\/produkt\/moonlighting-proteins-1\/","low_price_merchant_name":"Orell F\u00fcssli"}

CHF 17.00

Der Protein-Optimierer

CHF 16.00

Protein-Power

CHF 49.90

Protein crystals

Crystallization of proteins was in past decades mostly used to prepare large and highly pure crystals, to determine the structure of the protein crystals by X-ray measurements. With the increase of industrial applications of proteins [Bre08], the desired amount of high purity proteins is increasing, too. Crystallized proteins offer an improved shelf life with a very high degree of pre...