Foreword Mark T. Nelson I. Ion channel regulation of vascular tone and blood flow. Changes with hypertension. I.1. Endothelial cells I.1.1. Endothelial cell ion channel expression and function in arterioles and resistance arteries William F. Jackson I.1.2. Contribution and Regulation of Calcium channels in Endothelial Cells Kwong Tai Cheng, Avia Rosenhouse-Dantsker, and Asrar B. Malik I.1.3. Mitochondrial depolarization in endothelial and other vascular cells and their role in the regulation of cerebral vascular tone David W. Busija, Ibolya Rutkai, and Prasad V. Katakam I.1.4. Ion channels in Hypertension and Control of Blood Flow: Electrical conduction along endothelium of resistance arteries Erik J. Behringer and Steven S. Segal I.1.5. Ca2+/calmodulin-gated small- and intermediate-conductance KCa channels in cardiovascular regulation: Targets for novel pharmacological treatments Ralf Köhler. Aida Olivan-Viguera I.2. Smooth Muscle Cell I.2.1. Regional Variation in Arterial Myogenic Responsiveness - Links To Potassium Channel Diversity/Function Michael A. Hill, Yan Yang, Zahra Nourian, Barry D. Kyle, Kwangseok Hong and Andrew P. Braun I.2.2. Ion Channel Trafficking and Control of Arterial Contractility M. Dennis Leo and Jonathan H. Jaggar I.2.3. Abnormalities of Vascular Ion Channels during Hypertension II. Ion channels in the regulation of cell proliferation, remodeling, hypertrophy and angiogenesis II.1. Calcium Mobilization via Intracellular Ion Channels, Store Organization and Mitochondria in Smooth Muscle John G. McCarron, Susan Chalmers, Calum Wilson & Mairi E. Sandison II.2. Role of mechanosensitive TRP channels in Abnormal Vasculature of Tumors Holly C. Cappelli, Roslin J. Thoppil, Ravi K. Adapala, J. Gary Meszaros, Sailaja Paruchuri, and Charles K. Thodeti II.3. TRPC and Orai channels in store-operated calcium entry and vascular remodeling David J Beech, Jing Li, Lynn McKeown, and Hollie L Appleby II.4. Smooth muscle cell ion channels in pulmonary arterial hypertension: pathogenic role in pulmonary vasoconstriction and vascular remodeling Ramon J. Ayon, Haiyang Tang, Ruby A. Fernandez, Ayako Makino, and Jason X.-J. Yuan III. Ion channel regulation by lipids and channel modifications in metabolic disease III.1. Physiological roles and cholesterol sensitivity of endothelial inwardly-rectifying K+ channels: specific cholesterol-protein interactions through non annular binding sites Irena Levitan, Sang Joon Ahn, Ibra Fancher, Avia Rosenhouse-DantskerIII.2. Membrane lipids and modulation of vascular smooth muscle ion channels Alex M. Dopico, Anna N. Bukiya and Guruprasad Kuntamallappanavar III.3. Transient receptor potential channels in metabolic syndrome-induced coronary artery disease Stacey L. Dineen, Zachary P. Neeb, Alexander G. Obukhov, and Michael Sturek III.4. Mitochondrial ion channels in metabolic disease Aaron H Truong, Saravanakumar Murugesan, Katia D Youssef, and Ayako Makino Index... Mehr