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Increased sympathetic nerve activity plays a major role in the pathogenesis of hypertension. There is an increased sympathetic nerve activity in hypertension not just because of the pathogenesis of primary hypertension, but because of parasympathetic dysfunction. Peripheral sensory neuropathy also can be observed in hypertension without diabetes mellitus. In resistant hypertension, a neurovascular pulsatile compression of the brain stem on the left side may cause sustained sympathetic overactivity,... Mehr