Structural Genomics and Drug Discovery

1. Data Management in the Modern Structural Biology and Biomedical Research EnvironmentMatthew D. Zimmerman, Marek Grabowski, Marcin J. Domagalski, Elizabeth M. MacLean, Maksymilian Chruszcz, and Wladek Minor2. Structural Genomics of Human ProteinsKhan Tanjid Osman and Aled Edwards3. Target Selection for Structural Genomics of Infectious DiseasesCorin Yeats, Benoit H. Dessailly, Elizabeth M. Glass, Daved H. Fremont, Christine A. Orengo 4. Selecting Targets from Eukaryotic Parasites for Structural Genomics and Drug DiscoveryIsabelle Q.H. Phan, Robin Stacy, and Peter J. Myler5. High Throughput Cloning for Biophysical ApplicationsKeehwan Kwon and Scott N. Peterson 6. Expression and Solubility Testing in a High Throughput EnvironmentKeehwan Kwon and Scott N. Peterson 7. Protein Production for Structural Genomics Using E. coli ExpressionMagdalena Makowska-Grzyska, Youngchang Kim,Natalia Maltseva, Hui Li, Min Zhou,Grazyna Joachimiak, Gyorgy Babnigg, and Andrzej Joachimiak8. Eukaryotic Expression Systems for Structural StudiesChristopher A. Nelson, William H. McCoy, and Daved H. Fremont9. Automated Cell-free Protein Production Methods for Structural StudiesEmily T. Beebe, Shin-ichi Makino, John L. Markley, and Brian G. Fox10. Parallel Protein PurificationLudmilla Shuvalova 11. Oxidative Refolding from Inclusion BodiesChristopher A. Nelson, Chung A. Lee, and Daved H. Fremont 12. High throughput Crystallization ScreeningT. Skarina, X. Xu, E. Evdokimova, A. Savchenko13. Screening Proteins for NMR SuitabilityAdelinda A. Yee, Anthony Semesi, Maite Garcia, and Cheryl H. Arrowsmith 14. Salvage or Recovery of Failed Targets by in situ ProteolysisYufeng Tong, Aiping Dong, Xiaohui Xu, and Amy Wernimont15. Salvage of Failed Protein Targets by Reductive AlkylationKemin Tan, Youngchang Kim, Catherine Hatzos-Skintges, Changsoo Chang, Marianne Cuff, Gekleng Chhor, Jerzy Osipiuk, Karolina Michalska, Boguslaw Nocek, Hao An, Gyorgy Babnigg, Lance Bigelow, Grazyna Joachimiak, Hui Li, Jamey Mack, Magdalena M. Makowska-Grzyska, Natalia Maltseva, Rory Mulligan, Christine Tesar, Min Zhou , and Andrzej Joachimiak 16. Salvage or Recovery of Failed Targets by Mutagenesis to Reduce Surface EntropyLukasz Goldschmidt, David Eisenberg, and Zygmunt S. Derewenda17. Data Collection for Crystallographic Structure DeterminationKanagalaghatta Rajashankar and Zbigniew Dauter18. Structure, Determination, Refinement, and ValidationGeorge Minasov and Wayne F. Anderson19. Virtual High-Throughput Ligand ScreeningT. Andrew Binkowski, Wei Jiang, Benoit Roux, Wayne Anderson, and Andrzej Joachimiak 20. Ligand Screening using Fluorescence Thermal Shift Analysis (FTS)Chi-Hao Luan, Samuel H. Light, Sara F. Dunne, and Wayne F. Anderson 21. Ligand Screening using Enzymatic AssaysKiira Ratia, Shahila Mehboob, and Hyun Lee22. Ligand Screening using NMRBenjamin E. Ramirez, Aleksandar Antanasijevic, and Michael Caffrey23. Screening Ligands by X-ray CrystallographyDouglas R. Davies24. Case Study - Structural Genomics and Human Protein KinasesJonathan M. Elkins... Mehr