Sodium Calcium Exchange: A Growing Spectrum of Pathophysiological Implications

Part I. Historical Perspective.- 1. Livin with NCX and Lovin It: 45 Year Romance.- 2. 20 Years from NCX Purification and Cloning: Milestones.- Part II Structural and Functional Aspects of NCX.- 3. Ca2+ Regulation in the Na+/Ca2+ Exchanger Features a Dual Electrostatic Switch Mechanism.- 4. Molecular Determinants of Allosteric Regulation in NCX Proteins.- 5. NCX1: Mechanism of Transport.- 6. Structural Studies of the Ca2+ Regulatory Domain of Drosophila Na+/Ca2+ Exchanger CALX.- 7. Interplay of Ca2+ and Mg2+ in Sodium-Calcium and in other Ca2+ Binding Proteins. Magnesium: Watchdog That Blocks Each Turn If Able.- Part III. Structural and Functional Aspects of NCKX.- 8. Functional and Structural Properties of the NCKX2 Na+-Ca2+/K+ Exchanger: a Comparison with the NCX1 Na+/Ca2+ Exchanger.- 9. NCKX5, a Natural Regulator of Human Skin Colour Variation Regulates the Expression of Key Pigment Genes mc1r and alpha-MSH, and Alters Cholesterol Homeostasis in Normal Human Melanocytes.- 10. Expression and Regulation of Sodium/Calcium Exchangers, NCX and NCKX, in Reproductive Tissues: Do They Play a Critical Role in Calcium Transport for Reproduction and Development?.- Part IV. Genetic and Epigenetic Regulation.- 11. Transcriptional Pathways and Potential Therapeutic Targets in the Regulation of NCX1 Expression in Cardiac Hypertrophy and Failure.- 12. Transcriptional Regulation of ncx1 Gene in the Brain.- Part V. Regulatory Mechanisms of NCX.- 13. Metabolic Regulation of the Squid Nerve Na+/Ca2+ Exchanger: Recent Developments.- 14. Regulation of Sodium-Calcium Exchanger Activity by Creatine Kinase.- 15. Coordinated Regulation of Cardiac Na2+ Exchanger and Na+-K+-ATPase by Phospholemman (FXYD1).- Part VI. Subcellular Localization and Function of NCX in Ca2+-Storing Organelles and Mitochondria.- 16. Mitochondria Na+-Ca2+ Exchange in Cardiomyocytes and Lymphocytes.- 17. New Insights in Mitochondrial Calcium Handling by Sodium/Calcium Exchanger.- Part VII. NCX in Neurodegenerative Diseases.- 18. Genetically-Modified Mice as a Strategy to Unravel the Role Played by the Na+/Ca2+ Exchanger in Brain Ischemia and in Spatial Learning and Memory Deficits.- 19. NCX as a Key Player in the Neuroprotection Exerted by Ischemic Preconditioning and Postconditioning.- 20. The Role of the Mitochondrial NCX in the Mechanism of Neurodegeneration in Parkinson's Disease.- 21. The Contribution of the Sodium-Calcium Exchanger (NCX) and Plasma Membrane Ca2+-ATPase (PMCA) to Cerebellar Synapse Function.- Part VIII. Emerging Role of NCX Activity in Immune and Glial Cells.- 22. Sodium-Calcium Exchanger Modulates the L-Glutamate Ca2+-signalling in Type-1 Cerebellar Astrocytes.- 23. Immunosupressive Drugs, Immunophilins and Functional Expression of NCX Isoforms.- 24. Calcium Influx Through Reversed ncx Controls Migration Of Microglia.- 25. Sodium Fluxes and Astroglial Function.- 26. New Roles of NCX in Glial Cells: Activation Of Microglia in Ischemia and Differentiation of Oligodendrocytes.- 27. Human Macrophages and Monocytes Express Functional Na+/Ca2+ Exchangers 1 and 3.- Part IX. NCX in the Hearth and Vascular Smooth Muscle.- 28. New Insights into the Contribution of Arterial NCX to the Regulation of Myogenic Tone and Blood Pressure.- 29. Toward an Understanding of the Complete NCX1 Lifetime in the Cardiac Sarcolemma.- Part X. NCX Role in Hypertension, Heart Failure, Ischemia-Reperfusion, Arrhythmias, and Diabetes.- 30. Cardiac Sodium-Calcium Exchange and Efficient Excitation-Contraction Coupling: Implications for Heart Disease.- 31. Cross-talk Between Plasma Membrane Na+/Ca2+ Exchanger-1 and TRPC/ORAI Containing Channels: Key Players in Arterial Hypertension.- 32. T-tubule Remodeling and Ryanodine Receptor Organization Modulate Sodium-Calcium Exchange.- 33. Na+/ Ca2+ Exchange and the Plasma Membrane Ca2+-ATPase in beta-Cell Function and Diabetes.- Part XI. NCX Partners in Ionic Homeostasis: ASIC, NMDA, NHE, and TRPC.- 34. The Na+/H+ Exchanger NHE5 is Sorted to Discrete Intracellular Vesicles in the Central and Peripheral Nervous Systems.- 35. The Role of Na+/H+ Exchanger Isoform 1 in Inflammatory Responses: Maintaining H+ Homeostasis of Immune Cells.- 36. Acid-sensing Ion Channels in Pathological Conditions.- 37. Non-Selective Cation Channels and Links to Hippocampal Ischemia, Aging and Dementia.... Mehr