Protein Expression in Down Syndrome Brain

Contents Decreased alpha-endosulfine, an endogenous regulator of ATP-sensitive potassium channels, in brains from adult Down syndrome patients Developmental instability of the cerebellum and its relevance to Down syndrome Expression of the multidrug resistance P glycoprotein (Pgp) and multidrug resistance associated protein (MRP1) in Down syndrome brains Deterioration of the transcriptional, splicing and elongation machinery in brain of fetal Down Syndrome Fetal life in Down Syndrome starts with normal neuronal density but impaired dendritic spines and synaptosomal structure Antioxidant proteins in fetal brain: superoxide dismutase-1 (SOD-1) protein is not overexpressed in fetal Down syndrome Glial-neurotrophic mechanisms in Down syndrome Aberrant expression of dihydropyrimidinase related proteins-2, -3 and -4 in fetal Down Syndrome brain Decreased protein levels of complex I 30-kDa subunit in fetal Down Syndrome brains Selective upregulation of the ubiquitin-proteasome proteolytic pathway proteins, proteasome zeta chain and isopeptidase T in fetal Down syndrome Functional genomics of Down Syndrome: a multidisciplinary approach Unaltered expression of Fas (CD95/APO-1), Caspase-3, Bcl-2 and Annexins in brain of fetal Down syndrome: evidence against increased apoptosis Alteration of caspases and other apoptosis regulatory proteins in Down syndrome Expression of apoptosis related proteins: RAIDD, ZIP kinase, Bim/BOD, p21, Bax, Bcl-2 and NF-kB in brains of patients with Down syndrome Increased brain protein levels of carbonyl reductase and alcohol dehydrogenase in Down Syndrome and Alzheimer's disease Carbohydrate handling enzymes in fetal Down Syndrome brain Changes in nicotinic acetylcholine receptor subunits expression in brain of patients with Down syndrome and Alzheimer's disease Protein levels of human peroxiredoxin subtypes in brains of patients with Alzheimer's disease and Down Syndrome Effects of a single transdermal nicotine dose on cognitive performance in adults with Down syndrome The brain in Down syndrome Decreased levels of ARPP-19 and PKA in brains of Down syndrome and Alzheimer's disease Increased protein levels of heterogeneous nuclear ribonucleoprotein A2/B1 in fetal Down syndrome brains Decreased protein levels of stathmin in adult brains with Down syndrome and Alzheimer's disease Molecular neuropathology of transgenic mouse models of Down syndrome... Mehr