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The complement system is an evolutionary ancient mechanism that plays an essential role in innate immunity and contributes to the acquired immune response. It is a versatile first line of defense of hosts against various pathogens. Three modes of activation, known as classical, alternative and lectin pathway, lead to the initiation of a common terminal lytic pathway. The terminal complement components (TCCs: C6, C7, C8A, C8B, and C9) are encoded by the genes C6, C7, C8A, C8B, C8G, and C9. Herein... Mehr