Neuropeptide Systems as Targets for Parasite and Pest Control

1. Receptor?Based Discovery Strategies for Insecticides and Parasiticides: A ReviewDebra Woods, Cheryl Butler, Tracey Williams and Karen GreenwoodAbstractIntroductionMechanistic Receptor?Based ScreensSelection of Compounds for Screening'Hit?to?Lead': Converting a Mechanistic Screen Active into a Lead MoleculeLead?to?Candidate: Identification of Molecules for Progressionto MarketConclusion and Discussion2. Nonpeptide Ligands for Peptidergic G Protein?Coupled ReceptorsTimothy G. GearyAbstractIntroductionDruggable Targets in Neuropeptidergic SignalingNeuropeptide?Targeted Drugs: Basic FeaturesHistorical PerspectivesScreening for Novel Nonpeptide LigandsDiscovery of Novel Nonpeptide Ligands through ScreeningDesignCurrent StatusApplications in Invertebrate Systems: General ConsiderationsConclusion3. Interaction of Mimetic Analogs of Insect Kinin Neuropeptides with Arthropod ReceptorsRonald J. Nachman and Patricia V. PietrantonioAbstractIntroductionFunctional Analysis of Arthropod Receptors Selective for Insect KininsChemical, Conformational and Stereochemical Aspects of Receptor InteractionInteraction of Biostable Insect Kinin Analogs with Receptors and Activity in In Vitro and In Vivo BioassaysC?Terminal Aldehyde Analogs of Insect KininsNonpeptide Mimetic Agonists/Antagonists of Expressed Insect Kinin ReceptorsProspects for Enhanced Topical and/or Oral BioavailabilityConclusion4. Neuropeptides in Helminths: Ocurrence and DistributionNikki J. Marks and Aaron G. MauleAbstractIntroductionNematode NeuropeptidesPlatyhelminth NeuropeptidesTargets for Parasite ControlConclusionNote Added in Proof5. Neuropeptide Physiology in HelminthsAngela Mousley, Ekaterina Novozhilova, Michael J. Kimber and Tim A. DayAbstractIntroductionNeuropeptide Function in NematodesNeuropeptide Function in PlatyhelminthsConclusion6. Neuropeptide Gene Fa milies in Caenorhabditis elegansChris Li and KyuhyungKimAbstractIdentification of Neuropeptide Genes in C. elegansExpression of Neuropeptide GenesCleavage and Processing of NeuropeptidesBiochemical Isolation of NeuropeptidesNeuropeptide FunctionBehaviors Affected by Multiple Classes of NeuropeptidesNeuropeptide ReceptorsPharmacology of FLP NeuropeptidesConclusion7. Control of Nematode Parasites with Agents Acting on Neuro?Musculature Systems: Lessons for Neuropeptide Ligand DiscoveryRichard J. Martin and Alan P. RobertsonAbstractThe Existing Anti?Nematodal Drugs with Effects on Neuromuscular SystemsResistance Is PredictedBroad Spectrum or Narrow SpectrumPotential Problems Associated with Neuropeptide Receptors as Target Sites for AnthelminticsHigh?Throughput Screens for Neuropeptide LigandsToxicity and SafetyConclusion8. Neuropeptide signaling in insectsMiriam Altstein and Dick R. NässelAbstractIntroductionNeuropeptides: Their biosynthesis, processing and expressionNeuropeptides families, GPCRs and peptide functionsInsect neuropeptides as potential targets for pest managementConclusionAddendum9. Neuropeptide Physiology in InsectsWilliam G. BendenaAbstractIntroductionNeuropeptide Biosynthesis and ActionPotential Physiological Targets for Pest ControlFuture DevelopmentsConclusion10. Neuropeptide Biology in DrosophilaElke Clynen, Ank Reumer, Geert Baggerman, Inge Mertens and Liliane SchoofsAbstractIntroduction: Drosophila as a Model to Study Neuropeptide SignalingBioinformaticsNeuropeptidomicsDeorphanization of Drosophila Neuropeptide GPCRsFunctional Role of Neuropeptides: Localization, Reverse Genetics and BioassaysOther Neuronal Molecules as Potential Targets for InsecticidesConclusion11. Neuropeptide Receptors as Possible Targets for Development of Insect Pest Control AgentsMatthias B. Van Hiel, Tom Van Loy, Jeroen Poels, Hans Peter Vandersmissen,Heleen Verlinden, Liesbeth Badisco and Jozef Vanden BroeckAbstractIntroductionReceptors Controlling Insect... Mehr