Part I. Toxicoproteomics1. Array-Based Immunoassays with Rolling-Circle Amplification DetectionKatie Partyka, ShuangshuangWang, Ping Zhao, Brian Cao, and Brian Haab2. Analysis of Protein Changes Using Two Dimensional Difference Gel ElectrophoresisWeimin GaoPart II. Toxicant-Induced Inflammation3. Assessment of Pathological and Physiological Changes in Mouse Lung Through Bronchoalveolar LavageYuanpu Peter Di4. Analysis of Clinical and Biological Samples Using Microsphere-Based Multiplexing Luminex SystemYingze Zhang, Rahel Birru, and Y. Peter DiPart III. Gene Promoter Methylation5. Detection of DNA Methylation by MeDIP and MBDCap Assays: An Overview of TechniquesHang-Kai Hsu, Yu-I Weng, Pei-Yin Hsu, Tim H.-M. Huang, and Yi-Wen Huang6. Screening of DNA Methylation Changes by Methylation-Sensitive Random Amplified Polymorphic DNA-Polymerase Chain Reaction (MS-RAPD-PCR)Kamaleshwar P. SinghPart IV. Array Technologies7. Strategies for Measurement of Biotransformation Enzyme Gene ExpressionMarjorie Romkes and Shama C. Buch8. Genotyping Technologies: Application to Biotransformation Enzyme Genetic Polymorphism ScreeningMarjorie Romkes and Shama C. Buch9. TaqMan Fluorogenic Detection System to Analyze Gene Transcription in Autopsy MaterialKaori Shintani-Ishida, Bao-Li Zhu, and Hitoshi MaedaPart V. Analysis of DNA Adducts10. 32P-Postlabelling Analysis of DNA AdductsDavid H. Phillips and Volker M. Arlt11. Modification of the 32P-Postlabeling Method to Detect a Single Adduct Species as a Single SpotMasako Ochiai, Takashi Sugimura, and Minako Nagao12. DNA Isolation and Sample Preparation for Quantitation of Adduct Levels by Accelerator Mass SpectrometryKaren H. Dingley, Esther A. Ubick, John S. Vogel, Ted J. Ognibene, Michael A. Malfatti, Kristen Kulp, and Kurt W. Haack13. Analysis of DNA Strand Cleavage at Abasic SitesWalter A. Deutsch and Vijay HegdePart VI. Detection of Chromosomal and Genome-Wide Damage14. Premature Chromosome Condensation in Human Resting Peripheral Blood Lymphocytes without Mitogen Stimulation for Chromosome Aberration Analysis Using Specific Whole Chromosome DNA Hybridization ProbesRupak Pathak and Pataje G. S. Prasanna15. Mutagen Sensitivity as Measured by Induced Chromatid Breakage as a Marker of Cancer RiskXifeng Wu, Yun-Ling Zheng, and T. C. Hsu16. Pulsed-Field Gel Electrophoresis Analysis of Multicellular DNA Double-Strand Break Damage and RepairNina Joshi and Stephen G. GrantPart VII. Detection and Characterization of Surrogate Gene Mutation17. Detection of Pig-a Mutant Erythrocytes in the Peripheral Blood of Rats and MiceVasily N. Dobrovolsky, Xuefei Cao, Javed A. Bhalli, and Robert H. Heflich18. The Blood-Vased Glycophorin A Human In vivo Somatic Mutation AssayNicole T. Myers and Stephen G. Grant19. Flow Cytometric Quantification of Mutant T Cells with Altered Expression of the T-Cell Receptor: Detecting Somatic Mutants in Humans and MiceSeishi Kyoizumi, Yoichiro Kasunoki, and Tomonori Hayashi20. Analysis of in Vivo Mutation at the HPRT and TK Genes of Mouse LymphocytesVasily N. Dobrovolsky, Joseph G. Shaddock, and Robert H. Heflich21. Quantifying In Vivo Somatic Mutations Using Transgenic Mouse Model SystemsRoy R. Swiger22. The Human T-Cell Cloning Assay: Identifying Genotypes Susceptible to Drug Toxicity and Somatic MutationSai-Mei Hou23. Molecular Analysis of HPRT Mutations in Human LymphocytesPhouthone Keohavong, Liqiang Xi, Stephen G. and Grant24. Simultaneous Quantification of t(14,18) and HPRT Exon 2/3 Deletions in Human LymphocytesJames C. FuscoePart VIII. Detection and Characterization of Cancer Gene Mutation25. Mutation Screening of the TP53 Gene by Temporal Temperature Gel ElectrophoresisTherese Sørlie, Hilde Johnson, Phuong Vu, Guro Elisabeth Lind, Ragnhild Lothe, and Ann... Mehr
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