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Periodontitis is an infection-driven chronic inflammatory disease that affects the integrity of tooth-supporting tissues. Over the last two decades it has become more evident that although oral microorganisms are essential agents of periodontal pathogenesis, interpatient variability in the host response is a major determinant of the expression of periodontal disease extent and severity. The shift in paradigms to a concentration on the host response has led to the development of host-modulatory therapies... Mehr