undefined, Generation of Long Acting Therapies Using Glycosylated Linkers,
undefined, Generation of Long Acting Therapies Using Glycosylated Linkers,

The current therapeutic drugs such as, growth hormone (GH), granulocyte colony stimulating factor (GCSF) require once daily injections, which are inconvenient and expensive. A number of approaches to reducing therapeutic regimens clearance have been tried mainly through conjugation with another moiety such as, PEGylation, but this has been shown to be non biodegradable and toxic. Asterion has shown that the use of glycosylated linkers between two GH ligands to create protein tandems resulted in their... Mehr

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