undefined, Cystic Fibrosis Transmembrane Conductance Regulator,
undefined, Cystic Fibrosis Transmembrane Conductance Regulator,
undefined, Cystic Fibrosis Transmembrane Conductance Regulator, undefined, Cystic Fibrosis Transmembrane Conductance Regulator,

Cystic fibrosis (CF) is caused by the dysfunction of cystic fibrosis transmembrane conductance regulator (CFTR). The predominant mutation found in CF patients (delta F508) results in a mislocalized channel, which is unable to reach the plasma membrane. Rab proteins are small GTPases involved in vesicle transport. The regulation of CFTR by Rab GTPases-4 and 27a was evaluated in multiple cell systems: the colorectal HT-29 cells, bronchial epithelial IB3-1 and S9 cells. Over-expression of Rab proteins... Mehr

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