Cystic fibrosis (CF) is caused by the dysfunction of cystic fibrosis transmembrane conductance regulator (CFTR). The predominant mutation found in CF patients (delta F508) results in a mislocalized channel, which is unable to reach the plasma membrane. Rab proteins are small GTPases involved in vesicle transport. The regulation of CFTR by Rab GTPases-4 and 27a was evaluated in multiple cell systems: the colorectal HT-29 cells, bronchial epithelial IB3-1 and S9 cells. Over-expression of Rab proteins... Mehr