Cancer Vaccines

Part I: Manipulation and Modification of Immune Cells: Dendritic Cells1. Single Step Antigen Loading and Maturation of Dendritic Cells Through mRNA Electroporation of a Tumor-Associated Antigen and a TriMix of Costimulatory Molecules Daphné Benteyn, An M.T. Van Nuffel, Sofie Wilgenhof, and Aude Bonehill2. Generation of Multiple Peptide Cocktail-Pulsed Dendritic Cells as a Cancer Vaccine Hyun-Ju Lee, Nu-Ri Choi, Manh-Cuong Vo, My-Dung Hoang, Youn-Kyung Lee, and Je-Jung Lee3. Pulsing Dendritic Cells with Whole Tumor Cell Lysates Laura Alaniz, Manglio M. Rizzo, and Guillermo Mazzolini4. Antigen Trapping by Dendritic Cells for Anti-Tumor Therapy Chiranjib Pal5. Ex Vivo Loading of Autologous Dendritic Cells with Tumor Antigens Manglio M. Rizzo, Laura Alaniz, and Guillermo Mazzolini6. Tumor Antigen/Cytokine-Pulsed Dendritic Cells in Therapy Against Lymphoma Sumit K. Hira, Deepak Verma, and Partha P. Manna7. Dendritic Cells Primed with Protein-Protein Fusion Adjuvant Liying Wang and Yongli Yu8. Antigen-Specific mRNA Transfection of Autologous Dendritic Cells Fabian Benencia9. Electroporation of Dendritic Cells with Autologous Total RNA from Tumor Material Francesca Milano and K.K. Krishnadath10. Dendritic Cells Transfected with Adenoviral Vectors as Vaccines Joseph Senesac, Dmitry Gabrilovich, Samuel Pirruccello, and James E. Talmadge11. Genetic Modification of Dendritic Cells with RNAi Xiao-Tong Song12. Fast Monocyte-Derived Dendritic Cells-Based Immunotherapy Gamal Ramadan13. Intratumoral Injection of BCG-CWS Pretreated Dendritic Cells Following Tumor Cryoablation Naoshi Kawamura, Masaru Udagawa, Tomonobu Fujita, Toshiharu Sakurai, Tomonori Yaguchi, and Yutaka Kawakami14. Exploiting the CD1d-iNKT Cell Axis for Potentiation of DC-Based Cancer Vaccines Roeland Lameris, Famke L. Schneiders, Tanja D. de Gruijl, and Hans J. van der VlietPart II: Manipulation and Modification of Immune Cells: T Lymphocytes and NK Cells15. Modification of T Lymphocytes to Express Tumor Antigens Aaron E. Foster and Xiao-Tong Song16. Genetic Modification of Mouse Effector and Helper T Lymphocytes Expressing a Chimeric Antigen Receptor Liza B. John, Tess M. Chee, David E. Gilham, and Phillip K. Darcy17. Genetic Modification of Cytotoxic T Lymphocytes to Express Cytokine Receptors Serena K. Perna, Barbara Savoldo, and Gianpietro Dotti18. Monitoring the Frequency and Function of Regulatory T Cells and Summary of the Approaches Currently Used to Inhibit Regulatory T Cells in Cancer Patients Chiara Camisaschi, Marcella Tazzari, Licia Rivoltini, and Chiara Castelli19. Cytokine Activation of Natural Killer Cells Syh-Jae Lin, Pei-Tzu Lee, and Ming-Ling KuoPart III: Manipulation and Modification of Tumor Cells20. Loading of Acute Myeloid Leukemia Cells with Poly(I:C) by Electroporation Eva Lion, Charlotte M. de Winde, Viggo F.I. Van Tendeloo, and Evelien L.J.M. Smits21. Autologous Tumor Cells Engineered to Express Bacterial Antigens Vijayakumar K. Ramiya, Maya M. Jerald, Patricia D. Lawman, and Michael J.P. Lawman22. Tumor Cell Transformation Using Antisense Oligonucleotide Mohamed R. Akl and Nehad M. Ayoub23. The Direct Display of Costimulatory Proteins on Tumor Cells as a Means of Vaccination for Cancer Immunotherapy Haval Shirwan, Esma S. Yolcu, Rajesh K. Sharma, Hong Zaho, and Orlando Grimany-NunoPart IV: Manipulation of Immune/Tumor Interactions24. Cloning Variable Region Genes of Clonal Lymphoma Immunoglobulin for Generating Patient-Specific Idiotype DNA Vaccine Soung-chul Cha, Hong Qin, Ippei Sakamaki, and Larry Kwak25. Heat Shock Proteins Purified from Autologous Tumors Using Antibody-Based Affinity Chromatography Christian Kleist, Marco Randazzo, Janina Jiga, and Peter Terness26. Invariant Chain-Peptide Fusion Vaccine Using HER-2/neu Sonia A. Perez, George E. Peoples, Michael Papamichail, and Constantin N. Baxevanis27. TLR-9 Agonist Immunostimulatory Sequence Adjuvants Linked to Cancer Antigens Hidekazu Shirota and Dennis M. Klinman28. Production of Multiple CTL Epitopes from Multiple Tumor-Associated Antigens Rena Morita, Yoshihiko Hirohashi, Munehide Nakatsugawa, Takayuki Kanaseki, Toshihiko Torigoe, and Noriyuki Sato29. Preparation of Polypeptides Comprising Multiple TAA Peptides Bing Ni, Zhengcai Jia, and Yuzhang Wu30. Idiotype Vaccine Production Using Hybridoma Technology Susana Inoges, Ascension Lopez-Diaz de Cerio, Helena Villanueva, Fernando Pastor, and Maurizio Bendandi31. Preparation of Cancer-Related Peptide Cocktails that Target Heterogeneously-Expressed Antigens Reshu Gupta and Pradip P SachdevaPart V: Delivery Mechanisms32. Making an Avipoxvirus Encoding a Tumor-Associated Antigen and a Costimulatory Molecule Paul M. Howley, Kerrilyn R. Diener, and John D. Hayball33. Bacterial Vectors for the Delivery of Tumor Antigens Yan Wang, Bertrand Toussaint, and Audrey Le Gouëllec34. Preparation of Peptide Microspheres Using Tumor Antigen-Derived Peptides Santwana Bhatnagar, Raza Ali Naqvi, Riyasat Ali, and D.N. Rao35. Production of Antigen-Loaded Biodegradable Nanoparticles and Uptake by Dendritic Cells Vijaya Bharti Joshi, Sean M. Geary, and Aliasger K. Salem36. Development of Plasmid-Lipid Complexes for Direct Intratumoral Injection Rama P. Kotipatruni and Ganji Purnachandra NagarajuPart VI: The Advances, Challenges, and Future of Cancer Vaccines37. The Use of Dendritic Cells for Peptide-Based Vaccination in Cancer Immunotherapy Mohamed L. Salem38. Advances in Host and Vector Development for the Production of Plasmid DNA Vaccines Juergen Mairhofer and Alvaro R. Lara39. Challenges Facing the Development of Cancer Vaccines Mayer Fishman40. Future of Cancer Vaccines Hauke Winter, Bernard A. Fox, and Dominik Rüttinger... Mehr