Teratogenicity Testing

Part I: Introduction to Teratology Testing 1. An Overview of Teratology            Ana M. Calado and Maria dos Anjos Pires 2. Teratology Study Guidelines: An Overview            Sofia Alves-Pimenta, Luís Félix, Bruno Colaço, Paula A. Oliveira, and Carlos Venâncio 3. Biological Concerns on the Selection of Animal Models for Teratogenic Testing            Sofia Alves-Pimenta, Bruno Colaço, Paula A. Oliveira, and Carlos Venâncio Part II: In Vitro-Based Teratology Screening 4. The Validated Embryonic Stem Cell Test with Murine Embryonic Stem Cells            Lauren M. Walker, Darcie L.V. McClelland-Descalzo, and Nicole I. zur Nieden 5. Human Pluripotent Stem Cells to Assess Developmental Toxicity in the Osteogenic Lineage            Joseph V. Madrid, Steven R. Sera, Nicole R.L. Sparks, and Nicole I. zur Nieden 6. Chick Embryonic Cardiomyocytes Micromass System for Assessing Developmental Cardiotoxicity of Drugs            Wasay M.S. Qureshi and Margaret K. Pratten 7. Flow Cytometry to Evaluate Potential Developmental Toxicants in the Embryonic Stem Cell            Valéria Maria Lara, Kelly C. Santos Roballo, André Tadeu Gotardo, and Carlos Eduardo Ambrósio 8. Morphology-Based Whole Embryo Culture for Developmental Toxicity of Drugs            Bo Liang and Chi C. Wang 9. Western Blot Methodologies for Analysis of In Vitro Protein Expression Induced by Teratogenic Agents            Carlos Martins-Gomes and Amélia M. Silva 10. Manipulation of MicroRNAs in Cultured Mouse Embryos: Applications for Developmental Toxicology            Fuqiang Yuan and Shao-yu Chen Part III: Animal-Based Teratology Methods 11. Insights into the Phenotypic and Behavioral Effects of Teratogenic Drugs in Caenorhabditis elegans            Caralina M. de Evsikova 12. Effect of Teratogens on Development of Drosophila melanogaster            Dong Li and Xiaolin Bi 13. Cellular Responses in Drosophila melanogaster Following Teratogen Exposure            Matheus C. Bianchini, José L.R. Portela, Robson L. Puntel, and Daiana S. Ávila 14. Behavioral Teratogenesis in Drosophila melanogaster            Monalisa Mishra and Bedanta Kumar Barik 15. Evaluation of the Teratogenicity of Pharmaceuticals Using FETAX            Hariz Islas-Flores, Itzayana Pérez-Alvaréz, and Leobardo M. Gómez-Oliván 16. Histological Observation of Teratogenic Phenotypes Induced in Frog Embryo Assays            Mark E. Pownall and Margaret S. Saha 17. Visualization of Gene Expression Patterns by In Situ Hybridization on Early Stages of Development of Xenopus laevis            Heithem M. El-Hodiri and Lisa E. Kelly 18. Analysis of Lethality and Malformations During Zebrafish (Danio rerio) Development            Azhwar Raghunath and Ekambaram Perumal 19. General Whole-Mount Immunohistochemistry of Zebrafish (Danio rerio) Embryos and Larvae Protocol            Dércia Santos, Sandra M. Monteiro, and Ana Luzio 20. Geometric Morphometrics as a Tool to Evaluate Teratogenic Effects in Zebrafish (Danio rerio)            Kathryn E. Perez and Tisha C. King-Heiden 21. Live Metabolic Profile Analysis of Zebrafish Embryos Using a Seahorse XF 24 Extracellular Flux Analyzer            Simon T. Bond, Kevin A. McEwen, Prusothman Yoganantharajah, and Yann Gibert 22. Behavioral Profiling of Zebrafish (Danio rerio) Larvae Following Teratogen Exposure            Ana M. Valentim 23. Omics in Zebrafish Teratogenesis            Benjamin Piña, Laia Navarro, Carlos Barata, Demetrio Raldúa, Rubén Martínez, and Marta Casado 24. Proteomic Analysis of Zebrafish (Danio rerio) after Chemical Exposure            Yew Mun Lee, Caixia Li, Siew Hong Lam, Zhiyuan Gong, and Qingsong Lin 25. Immunohistochemical Assessment as a Tool for Investigating Developmental Toxicity in Zebrafish (Danio rerio)            Carla Santos and Maria de Lurdes Pinto 26. Oxidative Stress Assessment in Zebrafish Larvae            Inês Domingues and Carlos Gravato 27. Hemodynamic Studies for Analyzing the Teratogenic Effects of Drugs in the Zebrafish Embryo            Huseyin C. Yalcin 28. Western Blot Analysis and Immunostaining for Prediction of Embryotoxicity in Mus musculus            Yulia Irnidayanti, Win Darmanto, and Dias R. Sutiono 29. Histological and Histochemical Profile for Teratological Assessment in Mus musculus            Maria de Lurdes Pinto and Paula Rodrigues 30. In Vivo Analysis of Apoptosis in Embryonic Hippocampus            Ahmad Salimi and Jalal Pourahmad 31. Measurement of Mitochondrial Toxicity Parameters in Embryonic Hippocampus            Ahmad Salimi and Jalal Pourahmad 32. Animal Tests for Evaluation of Cognitive Impairment in Neonatal Mouse            Ahmad Salimi and Jalal Pourahmad 33. Methodology of Genotoxic and Teratogenic Studies in Rats            Eyyup Rencuzogullari and Muhsin Aydin 34. Whole Mount In Situ Hybridization and Morphometric Analysis in Rabbit Embryos            Yoshinori Kawamura and Kiyoshi Matsumoto Glossary of Key Terms for Teratology            Maria dos Anjos Pires and Ana M. CaladoIndex... Mehr