Protein Aggregation in Bacteria

Focuses on the aggregation of recombinant proteins inbacterial cells in the form of inclusion bodies--and on theiruse in biotechnological and medical applications The first book devoted specifically to the topic of aggregationin bacteria, Protein Aggregation in Bacteria: Functional andStructural Properties of Inclusion Bodies in Bacterial Cellsprovides a large overview of protein folding and aggregation,including cell biology and methodological aspects. It summarizes,for the first time in one book, ideas and technical approaches thatpave the way for a direct use of inclusion bodies inbiotechnological and medical applications. Protein Aggregation in Bacteria covers: * Molecular and cellular mechanisms of protein folding,aggregation, and disaggregation in bacteria * Physiological importance and consequences of aggregation forthe bacterial cell * Factors inherent to the protein sequence responsible foraggregation and evolutionary mechanisms to keep proteinssoluble * Structural properties of proteins expressed as solubleaggregates and as inclusion bodies within bacterial cells both froma methodological point of view and with regard to their similaritywith amyloids * Control of the structural and functional properties ofaggregated proteins and use thereof in biotechnology andmedicine Protein Aggregation in Bacteria is ideal for researchersin protein science, biochemistry, bioengineering, biophysics,microbiology, medicine, and biotechnology, particularly if they arerelated with the production of recombinant proteins andpharmaceutical science.... Mehr